Endocrine Abstracts

Introduction: Obesity is a complex and multifactorial disease with a chronic and relapsing nature, and is associated with over 200 co-morbidities. In a minority of patients, the obesity is caused by gene defects in the leptin-melanocortin pathway. As lifestyle interventions often fail in these patients, additional anti-obesity pharmacotherapy is needed. In this case report, we describe the therapeutic journey of a patient with early-onset obesity and hyperphagia due to heteroz...

Background: Obesity (BMI< 30 kg/m2) is a chronic and progressive disease, that is associated with many co-morbidities such as cardiovascular and psychiatric diseases, cancer, and arthritis. Lifestyle interventions are the cornerstone of obesity treatment, but when ineffective, anti-obesity pharmacotherapy could be added. In recent years, several anti-obesity agents have been approved, such as the glucagon-like peptide -1 (GLP-1) analogue liraglutide. Liraglutide...

Background: Altered signaling of hormones regulating appetite and metabolism is often observed in individuals with obesity (BMI ≥ 30 kg/m2) and related diseases, potentially resulting in increased hunger signaling and metabolic dysfunctions. Previous research indicates that such disturbances may be induced by weight gain itself, but also by other factors such as glucocorticoid excess (e.g. due to stress). However, knowledge regarding the associations between h...

Background: Obesity (BMI ≤ 30 kg/m2) is a chronic and relapsing disease, associated with numerous co-morbidities. Lifestyle intervention is the cornerstone of treatment of obesity, and is considered effective when weight loss of ≤ 5% is achieved. Here, we describe changes in physiological, psychological and behavioral health outcomes in response to a multidisciplinary combined lifestyle intervention (CLI).MethodsIn this longitudinal study we evaluated 97...

BackgroundLong-term glucocorticoids, as measured in scalp hair (HairGC), are associated with obesity and the metabolic syndrome (MetS). It is not known whether this represents a state of obesity or whether chronic hypercortisolism may influence the course or reversibility of obesity. In this study we longitudinally examine the relation between HairGC concentrations and metabolic syndrome parameters in patients with obesity who participate in a 1.5 year i...

IntroductionRecently, cross-sectional studies report associations between long-term glucocorticoid levels in scalp hair (HairGC) and obesity. However, there is a wide variation in studied outcomes and associations, possibly caused by differences in population characteristics, e.g. age, sex, dispersion of adiposity, and used laboratory methods. The aim of this systematic review and meta-analysis was to investigate the relation between HairGC and anthropom...